Tyrphostin AG 825: Product Description and Uses
Tyrphostin AG 825 is a potent and selective inhibitor of receptor tyrosine kinases, particularly targeting the epidermal growth factor receptor (EGFR) and the platelet-derived growth factor receptor (PDGFR). This compound is widely utilized in research settings to study the signaling pathways involved in cell proliferation, differentiation, and survival. By inhibiting these receptors, Tyrphostin AG 825 can effectively block downstream signaling cascades, making it a valuable tool in cancer research and therapeutic development.
Uses of Tyrphostin AG 825
- Cancer Research: Primarily used to investigate the role of tyrosine kinases in tumorigenesis and cancer progression.
- Cell Signaling Studies: Helps in understanding the mechanisms of cell signaling pathways mediated by growth factors.
- Drug Development: Assists in the development of new therapeutic agents targeting tyrosine kinases.
- In Vitro Studies: Employed in various in vitro assays to assess cell viability, proliferation, and apoptosis in cancer cell lines.
Technical Data
| Property | Details |
|---|---|
| Chemical Name | Tyrphostin AG 825 |
| Molecular Formula | C₁₈H₁₈N₄O₄S |
| Molecular Weight | 378.43 g/mol |
| CAS Number | 154447-36-6 |
| Solubility | Soluble in DMSO, ethanol |
| Storage Conditions | Store at -20°C, protect from light |
| Purity | ≥ 98% (HPLC) |
| Application | Inhibitor of receptor tyrosine kinases |
| Target Receptors | EGFR, PDGFR |
| Form | Powder |
Key Features
- Selectivity: Tyrphostin AG 825 exhibits high selectivity for its target receptors, minimizing off-target effects.
- Research Applications: Its ability to inhibit key signaling pathways makes it an essential reagent in cancer biology and pharmacology.
- Ease of Use: The compound is easy to handle and can be incorporated into various experimental setups with minimal adjustments.
In summary, Tyrphostin AG 825 is a crucial compound for researchers exploring the intricate roles of receptor tyrosine kinases in cellular processes, particularly in the context of cancer. Its technical specifications and applications make it a valuable asset in both academic and pharmaceutical research environments.